How The Human Body Processes Cannabis

Beginner’s Guide To The Endocannabinoid System — The Reason Our Bodies So Easily Processes Cannabis

Dr. Allen, retired cardiac surgeon & cannabinoid research scientist enlightens us about the Endocannabinoid System.

In the future, perhaps 20 years from now, cannabis-based medicines will have a prominent place in the worldwide pharmacopeianaked-baby-makers again. Indeed, we might have even gotten there much faster if it hadn’t been for the draconian interference of the U.S. government. To this day, they are still blocking researchers from accessing cannabis to study. Countless thousands have died suffering and millions more continue to be denied access to plant-based medications that could not only mitigate their misery, but also possibly even cure them.Cannabis medications work so efficiently because of the endocannabinoid (EC) system, present in all humans and many animals as well. This system consists of a series of receptors that are configured only to accept cannabinoids, especially tetrahydrocannabinol (THC) and cannabidiol (CBD). Not enough research has been done on the other ones, cannabinol (CBN) and cannabigerol (CBG) plus others, to know much about their mechanisms of effect.This system, an integral part of our physiologies, was discovered in the mid-1990s by Israeli researcher Dr. Ralph Mechoulam who also identified THC as the main active ingredient in cannabis in the early 1960s. Israel has been one of the most progressive nations for cannabis research and currently has one of the most advanced medical marijuana programs in the world. They are international leaders in advanced greenhouse technology, routinely producing flowers with 20 percent or greater THC.Dr. Mechoulam’s world-changing research discovered two main receptors, cannabinoid 1 (CB1) and cannabinoid 2 (CB2), that are keyed to both the endocannabinoids that our body naturally produces and phytocannabinoids (plant-based) like THC and CBD. Our bodies actually produce the ECs similar to how our body produces narcotic-like endorphins. Synthetic cannabinoids, like the ones found in Marinol, also fit the receptor sites but don’t work as efficiently as the natural ones.

This research barely created a stir when first published as the whole world was still wrapped up in drug war madness. A prominent scientist discovers that our bodies not only have receptor sites cued just for cannabinoids but that our bodies actually produce them internally. The next step was to figure out how this affects our body’s functioning.


CB1 receptors are primarily found in the brain, although they are also both present in the male and female reproductive organs. Current research shows that THC is specifically keyed to the CB1 site. Therefore it is responsible for the feeling of intoxication that is the most familiar aspect of cannabis. From a therapeutic standpoint, it’s most important effect is to modulate and moderate the perception of pain. For example, touching a finger to a hot stove sends an electrical impulse that goes from the finger to the brain. The brain replies, “ouch, hot” and the finger is pulled away.

THC moderates pain; this doesn’t mean we leave our finger on the stove, but that the intensity of the painful feeling is reduced when THC is present in the CB1 site. This mechanism of action is why THC-rich medicines are so prized by people with intense pain issues. Cannabis and narcotics are also co-agonists, which means that each of them magnifies the effect of the other. This allows people to take lower doses and still have it be effective. Additionally, CB1 receptors are not present in the part of the brain that regulates heart rate and respiration, so unlike narcotics, there is no lethal dosage threshold for THC, allowing someone to consume as much is needed for its palliative effects.

polsreefer39762_thumbCB2 receptors are primarily found in the immune system with the highest concentration located in the spleen. There is some evidence that the receptors might also be in the micro parts of the brain’s basal ganglia, or nerve bundles. Again, a lack of comprehensive research has left many without the knowledge that should be widely available.

The CB2 receptors are keyed to CBD and works as an anti-inflammatory agent. The immune-boosting functions of CB2 are far less understood as research into CBD is just really beginning. It’s only been about five years since CBD re-emerged in the medical cannabis scene and was identified through Steephill Labs. The benefits of CBD-rich medicine, with its anti-spasmodic qualities, is one the most exciting and promising areas of cannabis medical research currently happening. One of the other effects of CBD is that it moderates the effects of THC. It actually knocks THC off the CB1 receptor, so if someone is experiencing THC intoxication, a strong dose of CBD can counteract those effects. The future of CBD-rich medicines is almost limitless. Indeed, we have just barely scratched the surface of planet cannabis.

THC and CBD are the two main cannabinoids that are focused on, however there are dozens and possibly hundreds more. Some of the ones that have been identified and studied include CBG, which binds to both CB1 as well as CB2 and is an antagonist to CB1, meaning that it moderates the effects of THC. Cannabichromene (CBC) is non-psychoactive and has both anti-inflammatory and analgesic properties. CBN occurs when THC degrades. For this reason, it is rarely seen in fresh cannabis and is only mildly psychoactive, having a mostly sleepy effect. Tetrahydrocannabivarin (THCV) is another cannabinoid usually found in central Asian and southern African strains that also acts as a THC antagonist. There are more cannabinoids than can be listed here and they all have the potential to be as life changing as CBD is turning out to be.

The fact that there is a system in our body that produces cannabinoids, and is specifically designed to accept just them, should be overwhelming proof of cannabis’ efficacy as a medicine. From the pain-killing effects of THC to the anti-spasmodic and anti-inflammatory properties of CBD, we have just scratched the surface of a world of possibilities. People are waking up to the benefits of these medicines as more researchers are exploring the infinite possibilities inherent in this seemingly simple plant. Future generations will look back and wonder why it took so long to figure this out.

Granny means business

Granny means business

h/t Patients For Medical Cannabis

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3 thoughts on “How The Human Body Processes Cannabis

  1. The other day I found a photo of myself in my early 20’s. It was 1968 or so. There I was looking very pretty smoking…. cannabis. Back then we had a direct line to Nepal so it was not in leaf form… Oh, those were the days. Anyhow, here I sit, many years later, still in very good basic health even if the teeth and joints are showing signs of … well deterioration. Sigh. I eat healthy with only the occasional downfall into crud and try to exercise. Minimally. At my age, I take one med a day with the infrequent use of a pain killer if need be, or something for indigestion. Minimally. I hate meds and look to anything, even weight loss (!) to heal problems, so far so good.

    What is my secret?

    I never stopped smoking except during pregnancy. I am sure of it. My flesh is so permeated with the stuff I don’t know what would happen if I stopped. Would I ache and sleep poorly? Probably. Needless to say when I travel by air I travel totally clean but where I live, almost everyone indulges and the laws are lenient. The next federal election this will be a big issue, all eyes on the legalization in various American states. When I look at laws where it is so criminalized, I am totally dumbfounded as to why! It just does not make sense, so I just go on my merry way, stuffed vaporizer nearby, and give thanks things are as they are where I happen to live.

    Your cartoons made me crack up. TY. Now to the pool. I vaped whilst reading this and am ready to swim awhile…..

    BTW Glad to see you made use of some of those images from the cartoons. LOVE the Konrad one “I want to have your baby!”. It is totally wicked and so bang on. I do miss his work, very wicked…

    Anyhow, Merry Spring and all that… time to hit the pool.


    • Hi Noor.

      I am convinced that long term cannabis smokers are healthier than other folks. Although I didn’t know it at the time when I was young (although I knew it helped me in various ways) , it truly is a medicine.


  2. Wow, no Jackass whisperers here…

    I saw Noors comments at Goon Squad about American Exceptionalism
    which is total JEW POO…24/7.

    like this Jew worshipper “James Dobson”…

    “We … are not simply ‘slouching toward Gomorrah,’ as Judge Robert Bork
    warned in his best-selling book; we are hurtling toward it,” .

    “The old earthen dam that has held and protected the reservoir of
    …..silly puddy/JEW POO….
    called euphemistically/oxymoronically
    “Judeo-Christian values” <——real source of STOOOOPID –
    since the days of “our” being sold into slavery
    { by FDR in March 1933 }–may-7-2015.html
    in direct opposition to “our” so-called Founding Fathers-
    ….. has given way.”
    Read more : about the TARES being rounded up and put into the fiery furnaces

    I’m trying to keep the maw on topic…sittin’ on that sack of seeds

    man was that a full moon last night


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